We know that there are limits to the physical punishment an avatar in the avatar state can endure before they're brought down based on Aang being taken down by Azula's lightning in the AS, so I don't doubt that enough bloodbending could overpower it as well.

R1: Base Yakone vs AS adult Aang

R2: Yakone in full moon vs AS adult Aang (if it's even quantifiable how much of a boost the moon gives waterbenders)

Off-topic, but I just finished season 1 and it's so good. Sad that Amon died the way he did, so he can't have a rematch with Korra, but it's a perfect end to him and his family's (sad) story.

RT

Aang

There isn't one for Yakone, but he only has one feat anyway