r/braincancer • u/stupidmadoka • 4d ago

Ki67 20% and astrocytoma grade 3

Before the surgery, the doctor said that the astrocytoma had all the features of grade 2. Histology increased the degree to grade 3. They found up to 5 mitoses in 10 fields of view and Ki67 up to 20%. I assume that this is a lot even for grade 3, and the tumor is very aggressive. The tumor consists of gemistocytes. The good news is that the tumor surgeon did a complete resection and the MRI results show no remnants. Further treatment involves radiation and chemotherapy. But I am very upset about Ki67. Can we expect long-term remission with such indicators?

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u/No_Confidence3700 4d ago edited 3d ago

While ki-67 is an important characteristic, what is equally or more important is molecular characteristics. If your tumor has favorable molecular traits, then it means you will respond well to treatment and hence your prognosis improves vastly. I think it's important.not to sweat too much about one parameter. This is a very complex issue and has so many layers and everything plays a role, starting from tumor size, KPS scores, molecular pathology, methylation score/%, age, EOR etc.

What does your pathology/IHC report say?