r/lungcancer • u/GoldAd799 • 10d ago
Targeted therapy no longer working
A family member was diagnosed with T2bN3M0 lung cancer a year ago. They were started on targeted therapy Osimertinib (otherwise called Tagrisso I believe). Initially this showed some really positive results, with the main mass reducing in size. However on the last scan, it showed the tumours have now increased in size. Now waiting to hear whether chemo/radiation will be the next steps. Has anyone else/family members also experienced targeted therapy no longer working? What treatment came next and how did this affect prognosis?
16
Upvotes
9
u/Impossible-State6621 Caregiver 10d ago
My wife has been on Osimertinib, and although she hasn't progressed just yet, it's inevitable.
There are a number of second-line treatments, which depend on how much progression occurs and how the cancer mutates. In some cases patients are prescribed radiotherapy and are able to continue on Osimertinib. In other cases, a biopsy shows that another form of targeted therapy can help. In yet other cases, chemo can be prescribed, or amivantamab, or datopotamab in combination with deruxtecan. And clinical trials may also be available.
It's a terrible waiting game, but the next steps should be clearer soon.