r/neuroendocrinetumors • u/MrBomb98 • Jul 24 '25

Using Ozempic during Neuroendocrine Tumor

THIS IS NOT MEDICAL ADVICE — DON’T CHANGE ANY MEDICATION WITHOUT TALKING TO YOUR DOCTOR

My mom has a type 2 diabetes for a few years, and for the past 2 years she's been using Ozempic to help manage her blood sugar levels.

2 months ago, she was diagnosed with pancreatic neuroendocrine tumor (PNET) and she is about to start PRRT in 2 weeks.

During this week visit we were advised to pause taking Ozempic for now, at least until we know more about her tumor, because relatively new research show that semaglutide (the active ingredient in Ozempic and similar drugs) might promote the growth of certain neuroendocrine tumors.

  • I'm not in any way an expert in this field and I don't suggest changing anything in your meds without consulting with your oncologist/Endocrinologist first.
  • I thought that because Ozempic is relatively common in handling diabetes it was important to raise awareness and people should know this and consult with their doctors about alternatives.
8 Upvotes
  • permalink
  • reddit

100% Upvoted

10 comments sorted by

View all comments

4

u/FaithSlayer6 Jul 24 '25

Again not advice here dont go jump on the Wegovy/Ozempic/GLP1 train, But I started taking it in Feb and have had the opposite results. My latest scan showed a decrease in my liver Mets. (like 1-2mm reduction in my sub centimeter tumors) I also had a reduction in my gastro symptoms (TMI but i went from having loose stools daily - to less than once per month.) My Net specialist approved my GLP1 before i filled the script and I am working with him and my PCP and we are monitoring. This is going to be unique to each person. Please please dont take anyone's word for it - go talk with your doctor(s).

1

u/MrBomb98 Jul 24 '25

Did you do any other treatment during this time?

3

u/FaithSlayer6 Jul 24 '25

Firstly - I was diagnosed in early 2021 and had multiple large mets and the primary (small bowel) removed via surgery in July of 2021. I've been on lanreotide injections every 4 weeks since 2021. And I get MRIs 2-3x annually and 1 Pet Dotatate annually. Prior imaging showed I have about 12 visualized liver mets. Those were stable or growing 1-2mm every year. The largest was 1.2 centimetres (12mm.) Other than lanreotide I haven't taken anything for the cancer - unless you count Imodium and Zofran for the carcinoid symptoms. (edited to add) I have no Pancreas involvement. I think that should be a huge consideration here.

1

u/Large-Ad-641 Jul 28 '25

I was prescribed Xermelo for the carcinoid symptom (diarrhea) that the 1x month Octreotide injection was not resolving fully.