r/science • u/FunnyGamer97 • 21h ago
Medicine Most US neurologists prescribing MS drugs have received pharma industry cash | Nearly 80% of US neurologists prescribing drugs for multiple sclerosis (MS) received at least one pharma industry payment, with higher volume prescribers more likely to be beneficiaries, 5 year study finds
https://www.eurekalert.org/news-releases/1095648190
u/NinjaLanternShark 21h ago
So how much are these docs getting paid?
The average individual amount received was US$779, but 10% of recipients amassed US$155.7 million between them
Holy snot! The average amount is $779 but among the top 10%, the average amount is $268,448!
US$50 was associated with a 10% greater likelihood of prescribing that company’s drugs
OK, this feels like it could be education. Come to a conference, learn about a drug, have a few drinks on us.
US$5000 with a 50% greater likelihood
And that's a kickback.
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u/Relax_Dude_ 21h ago edited 20h ago
As a physician I can maybe shed some light on this. I'm a pulmonologist, received maybe about $1500 in my lifetime from pharma. None in cash, just lunch and dinners. They might bring lunch for the entire clinic staff or trainees. They might host a dinner session where an expert will speak on the subject while we attend, ask questions, and get a free dinner. It adds up over the years. Lunch might be $20-30 while dinner might be a bit more. It can add up to a few hundred per year and over several years it can certainly add up to the thousands. The ones that are in the tens of thousands or hundreds of thousands are not because they're getting kickbacks for prescribing, it's usually some combination of consulting fees and/or flying them out to give talks. So it's not hard to imagine if theres some renounced expert who strongly believes in the drug would be willing to give educational talks to other neurologists about it. If they get flown out, their travel, hotel, food, and speaking fee will be paid for. That usually amounts to fees in the tens of thousands range over several years. The ones getting 100k+ are most likely to be in the form of research grants or consulting fees. A research grant can easily be 100k for each individual grant. Thats just the reality of things. And while all this seems sketch to outsiders, I think there is some benefit to us attending these dinners and educational sessions. If theres new medications that actually work well and we're interested in prescribing them, we can pick the brains of these experts who are actually using it as well as the manufacturers themselves can guide us on how to get it through insurances. In my field, I was prescribing biologics for asthma. A new one came out a few years ago that I thought was fantastic on paper, could help alot of people for whom the other biologics weren't working. Theres some benefit in attending a dinner to ask them questions about the logics of administration, teaching, insurance coverage, dosing, certain adverse events to look for, etc. And of course for some of the more basic meds like inhalers they often give free samples which we're constantly giving them away to patients, preferably ones that are really tight on budget. I may give them samples to see if a certain inhaler works well for them before making them pay hundreds every month to maintain it. It's easy to say, "doctors are getting their pockets lined by big pharma" and get clicks but the reality is 99% of docs are just ordinary people who genuinely want to learn about the drug while also having a nice dinner with colleagues and de-stress a bit. Theres certainly bad apples out there, but thats the case with anything.
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u/TeleHo 16h ago
From what I understand, a ton of DMTs for MS came out in 2019-2020 (though someone can correct me if I'm wrong). Could it also be that neurologists are receiving larger consulting payments/research grants/etc. because the drugs are new enough that there's a lot of new research/information to be shared?
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u/MrHobodeluxe 21h ago
Great reply. I work in pharma development. Skepticism and mistrust are definitely understandable when folks haven't been exposed to the realities certain professions experience. It is difficult for people to understand how much things actually cost and why when they've never had any involvement. And to be fair, there are a lot of bad actors out there exacerbating mistrust.
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u/ycaivrp 3h ago
So, I was a measly resident who went to a thing hosted by Eli Lily during my Endo rotation, about mojaro. I didn't even get lunch! Nor a pen. Then I saw how much the endocrinologists loved it since they were already using it for a little bit. I then prescribed it for some of my patients the next month and it was insane. These people's glucose dropped from 400 all the time to 150/160. Some of them eventually cannot tolerate the side effect etc. Then what I did, I bought a a ton for Eli Lily stock. Okay. That's my story.
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u/Relax_Dude_ 2h ago
I think retatrutide is going to be a game changer once it goes through. But thats just my own reading, never attended an Eli Lilly talk nor do I prescribe these drugs.
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u/thinkbetterofu 12h ago
so, you, as a doctor, would be totally comfortable telling any patient you are prescribing a drug for, a full disclosure that you had previously entertained these outings, dinners, or paid speaking events, or trips, from the pharma companies of the drug you are prescribing?
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u/gearpitch 6h ago
Probably not, because people are too stupid to think critically and see the nuance of medical education. Doctors don't prescribe drugs they don't learn about, and that's almost entirely through company outreach. Patients are emotional and reactive, and would reject most medicine as sounding like a bribe. Aka like this study.
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u/Relax_Dude_ 6h ago edited 6h ago
I wouldn't mind a but i would need the time to explain all yhe above which would add another 10 min of back and fourth discussion which there isn't time for. And fyi, all of these "payments' including food or whatever are all publically available information. You can look up any individual, institution, or company and see who is paying who for what purpose down to the exact date.
I also want to say there is often a preconceived bias favorable to the drug before a doctor attends the event. For example I went to a Tezpire dinner because I wanted to prescribe it. I'm sure neurologists are going to dinners of these new MS drugs because they are already interested in it. I think this part gets completely missed is these discussions.
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u/pswissler 2h ago
I understand what you're saying here but in my job (professor at a public university) we're not even technically allowed to take free swag from suppliers at conferences due to the perceived conflict of interest it would result in. Honeraria for talks given is common but it's the sort of things we need to report to our ethics office.
When I worked in industry these sort of supplier lunches were more common, but the fundamental difference is that any induced bias started and ended internally, rather than propagating outward to the public at large.
"Everyone does it so it's not a big deal" is a poor argument and can only serve to erode trust in your profession. The fact that you acknowledge that it would require a detailed discussion with patients shows that you recognize this. I understand that entrenched field standards are difficult to change (especially since the status quo results in some nice perks for those in the field), but it's something that your field needs to start recognizing as a problem.
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u/Relax_Dude_ 2h ago
I totally understand but I also don't want to give into popular opinion if I strongly believe it's just wrong. All I really care about is my relationship and trust with my patients which I feel like I have. I know for a fact that I only make decisions with my patient's best interest in mind, and they know I go above and beyond for them. And if we're on the subject of erosion of trust in doctors, I would say a much larger percentage of that has to do with social media misinformation for clicks and it has to do with doctors not explaining their decision making or having the time to do so. Maybe 30 years ago if a doc told you to take this medication for your blood pressure, you'd take it no questions asked. Nowadays you have to explain what hypertension is, the consequences of untreated hypertension, what the drug does, less common side effects, etc. Theres nothing wrong with that but its often a time issue. Example: I had a friend's mom tell me the other day that her pulmonologist put her on an antibiotic to take long term. She feels like she doesn't have an infection and her sisters daughter is a nurse and told her she should never take long term antibiotics because it builds resistance and that that doctor didn't know what he was doing. She felt better when she was taking it but then stopped because of her nurse friend. So now they dont trust their doc and dont know what to do. I saw her med list and it was azithromycin 3x per week, it was for bronchiectasis. I explained to her that this is a perfectly good treatment, I explained why and how it works, and told her I would've done the same. I told her she should also be on certain other breathing treatments. She told me she was already on them. What I advised was exactly the same as what that pulmonologist advised. In one interaction theres mistrust, in the other interaction theres trust and comfort. I think those things factor more into mistrust than this idea that doctors are getting kickbacks, which btw are illegal and can get your medical license taken away.
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u/TheUnicornCowboy 14h ago
Your entire industry seems so far beyond corrupt it’s ridiculous, the fact that you think it’s ok to accept hundreds of thousands of dollars in kickbacks for prescribing particular drugs and that’s just an ok part of the job. THATS A BRIBE. Full stop. It’s insane reading that you think that’s normal and ok. I would have my license revoked in a heartbeat if I accepted a bribe in my field. Insane.
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u/Nyrin 14h ago
You either didn't actually read what you're replying to or didn't understand it.
The parent commenter made it explicitly clear that, even in the nominally large cases, it's not a kickback system. But you're peddling that to yourself anyway because hey, manufactured outrage.
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u/thinkbetterofu 12h ago
its an actual concern. and its absolutely a kickback. but reddit leans neoliberal and is okay with things as long as the system manufactures enough consent. and guess what, most of the people in this thread have a financial interest in keeping this system going, either working for the pharma companies or are doctors admitting to receiving the benefits reported on in the study. but please keep attacking the person who has a reasonable response of justified outrage at this system which does not benefit patients.
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u/FeelsGoodMan2 14h ago
This is why I think it's funny that people think there's a silver bullet to fixing the US healthcare system. Yeah there's certain things we need to fix, but there's a whole lots of parts of the system that will need to change and sacrifice for it all to get into a good place.
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u/MenWhoStareAtBoats 4h ago
What that physician described are not kickbacks. Accepting a kickback for medications prescribed is a felony and would definitely put the doctor’s license in jeopardy.
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u/NinjaLanternShark 20h ago
The data specific excludes consulting fees and research grants.
And no amount of "trust me, I'm a doctor" condescension will convince me that the best way for physicians to learn about new drugs is to have drug company salespeople wine and dine them.
The system is corrupt to the core.
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u/Relax_Dude_ 20h ago
I dont see where they excluded consulting fees, they include the consulting fee data in their tables. They only excluded research grants. Generally "Travel and lodging" for speaking is not categorized under "consulting fee". So thats sorta consistent with what I said that travel and lodging is the highest category, just like the study. I do think this is a 'correlation not causation', just my opinion. In my case I'm more likely to prescribe that biologic having attending the dinner and having gotten comfortable with it. If I didn't have anyone else to talk to about it, I might have referred my patients to someone else to do it, and that someone likely did have some contact with the company. You can believe whatever you want but believing this is a big conspiracy and doctors are somehow paid under the table just makes you sound like the crazy one.
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u/hal0t 11h ago edited 11h ago
Higher prescription volumes were associated with a greater likelihood of receiving any payment type
the highest number of discrete payments was made for food and drink.
I work in biotech sales ops, not pharma but pretty close, so I will shed some lights on how this work. We don't give people cash ever. But everything we spend on the clinic must be logged and uploaded to Open Paymenr system. $780 is only 2 lunches and some donuts/coffee run. Doctors don't keep track of all drugs and procedures on the market, they need a rep to talk to them about it, so obviously having received payment of any kind increase the likelyhood of prescribing drugs. $50 is less than a breakfast. Also, if you go in to a clinic, you better bring stuffs to the whole staffs to smoothing out with the admin so it's easier to make the next appointment, the doctors would get all of those data accounted underhim.
particularly for consulting services, non-consulting services, such as speaking at an event, and travel/accommodation.
We would find heavy users, recruit them to be our KOL and do speaker programs, talking about clinical pathway, how they adopt the product in their office etc. And also, doctors have totally different patient base (make up, size), so a lot of heavy hitters already see a lot of patients for a particular disease. So it's a correlation but not necessary causation. You see $5k and think it's a lot but it's only 10 or so hours of speaking a year. And there are events, tradeshows to go to every 2 weeks. It's beneficial for the doctors to hear expert talk about drugs, insurance converage, patient selection etc
All of these are heavily documented, and compliance watch the sales org like hawk. Ever since Sunshine act you have to be extra super sneaky to do something like bribing. The most I have seen is something like this group of doctors like to play golf, we hold a conference at a hotel with nice golf course, and we look the other way when they bring their hot gfs with them on the trip.
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u/NinjaLanternShark 6h ago
What you're describing, to the rest of us, is a corrupt system. I wish I could make you see it, but it's your livelihood so I totally understand why you can't.
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u/grasshopper239 21h ago
I'm not the smartest person ever. But pharmaceutical companies should be exclusively marketing to doctors, not to the public.
I want to throw up every time I hear "ask your prescriber" on TV
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u/NinjaLanternShark 20h ago
Pharma companies shouldn't be marketing to doctors either. They should publish their research and doctors should learn about new treatment options through unbiased continuing education.
What makes anyone think that the drug with the biggest marketing budget is automatically the best one to prescribe people?
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u/grasshopper239 20h ago
That sounds even better. All I know is the patient shouldn't be recommending drugs to the doctor
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u/opisska 12h ago
There are two different things here. I live in a country where ads for prescription drugs don't exist (I am not sure if they would even be legally possible), but still I think it's important for the patients to be informed about their choices.
Incidentally for this thread, I have MS myself. The various options differ heavily in possible side effects and general limitations on the recipient's life - and I have very different priorities than the average patient that comes into the office. Yes, it's important to discuss this with the doctor, but the time available for consultation is limited and it's far more efficient to come prepared - especially when you have considerations that the doctor almost never hears.
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u/andy013 6h ago
They shouldn't be involved in the research either. There are many examples where they have either outright lied or subtly biased the research to make their product look safer or more effective than it actually is. We must have independent scientists designing and conducting the testing for all drugs and medical devices.
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u/WillSupport4Food 10h ago
The issue is often funding. Someone has to pay for the CE. Someone has to pay to fly out the specialist to give the lecture, for the lecture hall, for housing of attendees if it's multiple days, and travel expenses. Often times it's either your employer or the company hosting the event because otherwise the alternative is the doctor pays for it themselves which create a financial disincentive to seek out valuable CEs.
Examining sources of bias in research is a fundamental part of science and just because research is published for a CE doesn't make it free of bias. It seems a little silly to trust a doctor to read research papers and pick out bias from an endless sea of new research, but the moment they're sitting at a lecture with a sales rep presenting a paper they're suddenly incapable of perceiving bias and forming their own professional opinion.
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u/theburiedxme 9h ago
Related anecdote, worked in an MS clinic pharmacy, they worked with docs to get most patients on a drug that just went generic, that costs us $2 to get but insurance were still reimbursing us $5000.
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u/glarbknot 4h ago
Remember when Perdue went around the nation with their new non habit forming pain killers?
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u/CuriousRexus 10h ago
Shocker. If you saw the perks doctors get for promoting crap, youd lose all trust
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